Nanoscale Biophysics

“Synonymous” mutations in the viral RNA sequence can change the size of the RNA, so that it no longer fits into the capsid, without changing the encoded protein.   This insight, from bioinformatical simulations, may be useful in the development of vaccines.  Image attributed to Luca Tubiana.
“Synonymous” mutations in the viral RNA sequence can change the size of the RNA, so that it no longer fits into the capsid, without changing the encoded protein. This insight, from bioinformatical simulations, may be useful in the development of vaccines. Image attributed to Luca Tubiana.

From single-molecule to viral particles, nanoscale biophysics explores how small numbers of molecules come together to achieve structural and functional versatility.  Proteins that form viral capsids, lipids that form transport vesicles, the chromatin assembly that controls DNA replication in higher organisms, and large enzymatic complexes that control metabolic pathways are all examples of nanoscale assemblies. Understanding gleaned from the study of these assemblies enables new technologies for drug delivery, nanofabrication, and translational medicine.